Brock Macdonald1, Evi Vakiani2, Rhonda K Yantiss3, Jun Lee4, Robert S Brown Jr5, Samuel H Sigal61Division of Gastroenterology, Department of Medicine, University of California-San Francisco, San Francisco, CA, 2Department of Pathology, Memorial Sloan–Kettering Cancer Center, New York, NY, 3Department of Pathology and Laboratory Medicine, New York Weill Cornell Medical College, New York, NY, 4Division of Nephrology, Department of Medicine, Weill Cornell Medical College, New York, NY, 5Division of Gastroenterology, Department of Medicine, Columbia University College of Physicians and Surgeons, New (...) York, NY, 6Division of Gastroenterology and Hepatology, Department of Medicine, New York University, New York, NY, USA: The use of sirolimus as an alternative to calcineurin inhibitors for posttransplant immunosuppression is associated with a variety of inflammatory conditions. In this report, we describe the case of a 34-year-old man who developed abnormal liver tests 6 years after live-donor kidney transplantation and 5 years after initiation of sirolimus-based immunosuppression. Elevated aminotransferase levels persisted after withdrawal of potentially hepatotoxic medications, and serologic evaluation for viral hepatitis, autoimmune disease, and genetic disorders was unrevealing. Liver biopsy revealed prominent hepatocellular injury associated with a mixed inflammatory infiltrate and liver tests normalized within 2 weeks of discontinuation of sirolimus. In this report, we review previous reports of sirolimus hepatotoxicity and propose a unifying hypothesis for the various inflammatory conditions that have been attributed to sirolimus.Keywords: sirolimus, immunosuppression, transplant, inflammatory conditions, hepatotoxicity. (shrink)

Organisational aesthetics is a burgeoning field with a growing community of scholars engaged in arts-based and aesthetic approaches to research. Recent developments in this field can be traced back to the works of early Enlightenment writers such as Vico, Baumgarten and Kant. This paper examines the contributions of these three philosophers. In particular it focuses on Vico’s treatment of history and myth; Baumgarten’s notion of sensation and its relationship to rationality; and Kant’s investigations into form and content. An exploration of (...) an artistic organisation in change demonstrates how the conduct of an aesthetically aware manager can be informed by qualities such as an alert imagination and intuition, comfort with the chaotic, backward thinking, and attention to inner sensations and perceptions, all working together to provide a coherent view of the organisation. (shrink)

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

The authors explore the changing dynamics of gendered familial caregiving in urban China within the context of economic reforms and the continued cultural influence of xiao. Data collected in China through interviews with 110 familial caregivers were used to examine cultural and structural influences on the caregiving behavior of adult children. Results from multiple regression analyses provide evidence of a gendered division of parental care tasks, a decline in the patrilocal tradition of caregiving, and a strong social pressure that influences (...) caregiving behavior. Structural factors linked to caregiving performance included family size, lack of pensions for elders, and caregivers’ employment status and income. Findings portend deleterious effects for the women who are now caregivers as they are likely to live longer but be more financially dependent and have fewer children available to help them. (shrink)

Here, Rhonda Martens offers the first extended study of Kepler's philosophical views and shows how those views helped him construct and justify the new astronomy.

In Aotearoa/new Zealand, organ donation and transplantation rates for Māori and non-Māori differ. This article outlines why this is so, and why some groups may be reticent about or object to organ donation and transplantation. In order to do this, I draw on the conceptual and methodological lens of phenomenology and apply what Van Manen calls the existential themes of lived body (corporeality), lived space (spatiality), lived time (temporality) and lived other (relationality and communality) to a discussion of the cultural (...) values and spiritual beliefs of Māori around tissue donation. Specifically, the aim of the article is to encourage non-Māori, who will already be aware that diverse cultural traditions transmit different beliefs about organ donation and transplantation, to recognize the existence of a deeper understanding of what this difference may mean for people on a felt level and how it might impact on lived experience. (shrink)

The February 2004 release of Mel Gibson’s The Passion of the Christ is a major cultural event. Receiving a tremendous amount of advance publicity due to claims of its anti-Semitism and adulatory responses by conservative Christians who were the first to see it, the film achieved more buzz before its release than any recent film in our memory.1 Gibson himself helped orchestrate the publicity with selective showings of The Passion and strategic appearances on TV shows where he came off as (...) something of a Hollywood eccentric, albeit one who was only too happy to admit to his past sins and to claim that he had achieved “salvation” through his adherence to Christianity. His film, he insisted, would be testament to the truth of Christ and how Christ died so that sinners like Gibson could be saved and enjoy eternal life. (shrink)

John Hartley opens his short history of cultural studies by evoking a sense of the contested nature of the field in the contemporary moment and the intense debates about its objects, scope, methods, and goals: “Even within intellectual communities and academic institutions, there is little agreement about what counts as cultural studies, either as a critical practice or an institutional apparatus. On the contrary, the field is riven by fundamental disagreements about what cultural studies is for, in whose interests it (...) is done, what theories, methods and objects of study are proper to it, and where to set its limits” (1). (shrink)

Set in the minimalist abode of a sparsely furnished hotel room, Awaiting Oblivion narrates the encounter between a man and a woman, anonymously known as Il and Elle, respectively. The plot revolves around their relationship, the nature of which is the concern of their dialogue. Their dialogue intermittently emerges through a narrative voice that is, however, infused with the very same confusion and vacillation as is their own speech. The man and woman are caught in an undulating relation of attraction (...) and repulsion, as they endeavour to rediscover the desire they once felt for one another. The themes of waiting and forgetting are manifested within the plot in their vain efforts to remember a past event whilst, paradoxically, simultaneously awaiting the event’s recurrence. This event constitutes their first encounter, the memory of which will affect their future relationship. However, each person has his own perception of how this initial encounter had transpired, the memory of which is constantly being revised, over time. The couple engage in lengthy conversations in their attempts to overcome this discrepancy. First, Il expresses his perception of the event. Sensing problematic elements in his account, Elle recounts her version of how things had transpired, while Il attempts accurately to transcribe her words. With time, Il and Elle are able to arrive at a mutually balanced view of the event. Ironically, it is through waiting and forgetting that they are able to arrive at this point. (shrink)

Since the 1988 Cartwright Inquiry, lay members of ethics committees have been tasked with ensuring that ordinary New Zealanders are not forgotten in ethical deliberations. Unlike Institutional Review Boards in North America, where lay members constitute a fraction of ethics committee membership, 50% of most New Zealand ethics committees are comprised of lay members. Lay roles are usually defined in very broad terms, which can vary considerably from committee to committee. This research queries who lay representatives are, what they do, (...) and what if anything they represent. Our findings are based on data collection with 12 participants: eight semi-structured interviews with lay members from diverse types of ethics committees who described their roles, and commentary from four ethics committee chairs, three of these lay members who commented on this article’s final draft. Findings indicate that the role of New Zealand lay persons – although distinctively valued – is otherwise similar to the documented role of lay persons within North American ethics committees. Lay members see their role as primarily protecting the research participant and at times offering a corrective to non-lay members’ views and the interests of their institutions. However, in spite of their numbers, most lay members do not see themselves as representing any particular constituent groups or institutionally unaffiliated areas of concern. On tertiary education committees especially, there is a good deal of ambiguity in the lay role. (shrink)

What is initially striking about Alfred Schutz’s phenomenological account of the musical experience, which encompasses both the performance and reception of music, is his apparent dismissal of the corporeal and spatial aspects of that experience. The paper argues that this is largely a product of his wider understanding of temporality wherein the mind and time are privileged over the body and space, respectively. While acknowledging that Schutz’s explicit or stated view is that the body and space are relatively insignificant to (...) his account, the paper reveals how they actually feature significantly in the latter, but in ways that remain largely implicit. First, the analysis demonstrates that the mental and temporal aspects of Schutz’s phenomenology of the musical experience cannot be considered independently of their interrelations with the equally important, albeit under-examined, corporeal, and spatial aspects. Concepts from Nietzsche’s early aesthetics are recruited to fulfil this task. Second, the analysis challenges Schutz’s dismissal of space in his theory of music perception. Lastly, it reveals the crucial, yet implicit, role of the body and space in his key examination of the intersubjective phenomenon he terms “making music together”. By presenting the above arguments, the paper aims to draw out the implicit dimensions of Schutz’s phenomenology of music and thereby enrich his influential account. (shrink)

What kinds of contributions can sociologists make to debates about ethics? What makes sociological investigation of morality and ethical issues distinct from philosophical concerns? Is there a place for a separate subfield within the discipline of sociology that deals specifically with questions of ethics and morality? This book places these questions on the sociological agenda. The first part of the book addresses the 'ethical turn' in sociology, and includes chapters on defining ethics and morality, lay understandings of ethics, sociological accounts (...) of moral life, and the relation of sociology to bioethics. These chapters examine alternative conceptions to mainstream discussions regarding embodiment and ethics. The book provides insight into both recent debates in the humanities and social sciences about the circulation and transfer of bodily fluids, tissues, and organs, and the gift-exchange, reciprocity practices, and institutions that make these body economies possible. (shrink)

Much of the human enhancement literature focuses on the ethical, social, and political challenges we are likely to face in the future. I will focus instead on whether we can make decisions to modify ourselves that are known to be likely to satisfy our preferences. It seems plausible to suppose that, if a subject is deciding whether to select a reasonably safe and morally unproblematic enhancement, the decision will be an easy one. The subject will simply figure out her preferences (...) and decide accordingly. The problem, however, is that there is substantial evidence that we are not very good at predicting what will satisfy our preferences. This is a general problem that applies to many different types of decisions, but I argue that there are additional complications when it comes to making decisions about enhancing ourselves. These arise not only for people interested in selecting enhancements but also for people who choose to abstain. (shrink)

Many feminist sociologists would agree that most breastfeeding research to date has been primarily undertaken from the perspective of medical and public health discourses. While there is evidence of a shift in research on breastfeeding to qualitative studies that focus on the lived experiences of breastfeeding women, this article addresses a number of concerns remaining in the literature surrounding breastfeeding. First, it questions the absence of breastfeeding as a legitimate philosophical topic, and, as a corollary, the invisibility of breastfeeding women (...) as moral or ethical subjects. Second, by drawing on Michel Foucault's account of ethics and Judith Butler's notion of performativity, it is suggested that breastfeeding is best conceptualized as a gendered and embodied ethical practice rather than an aspect of one's being. Finally, this materialist approach to theorizing breastfeeding is discussed in relation to the Lucy Lawless poster that was released in Aotearoa New Zealand to launch World Breastfeeding Week in August 2002. (shrink)

This article is designed to explore ideas in the recent sociology of morality about the conjunction of ethics and embodiment in everyday life. While it draws on an interpretation of the ethical encounter as a relation of moral proximity, it extends this conception of ethics beyond the dyad to include a discussion of gift giving and generosity in the present context. This is done in order to analyse a concrete empirical event in terms of the web of moral and social (...) codes that inform it. The event in question is a well-known New Zealand breastfeeding case in which a woman breastfed another woman's baby `without her consent'. As well as drawing attention to the ethical risks in encounters between strangers and others in contemporary social life, this particular breastfeeding case also brings to the fore the invisibility of breastfeeding as an embodied ethical practice. (shrink)

This article is an exploration of the ways in which maternal subjectivity is negotiated and defined in the context of the act or process of giving birth. As such, it is offered as a contribution to and discussion of recent feminist evaluation of childbirth management systems. Written from the partial perspective of my own experiences of pregnant and maternal embodiment, the article considers whether the ethic of the birth plan is a satisfactory representation of consumer needs and participation in contemporary (...) maternity care. By way of a selective personal account of various models of consumer-orientated and woman-centred childbirth management services that exist in Australia and New Zealand, I draw on ideas from feminist theories of corporeality and the dialogical tradition of social thought in order to rethink the ethical encounter between the labouring woman or consumer and her care provider or practitioner. (shrink)

Copernicus claimed that his system was preferable in part on the grounds of its superior harmony and simplicity, but left very few hints as to what was meant by these terms. Copernicus’s pupil, Rheticus, was more forthcoming. Kepler, influenced by Rheticus, articulated further the nature of the virtues of harmony and simplicity. I argue that these terms are metaphors for the structural features of the Copernican system that make it more able to effectively exploit the available data. So it is (...) a mistake to conclude that early Copernicans could only offer aesthetic or pragmatic arguments; they could and did offer evidential ones as well. Moreover, the evidential arguments they offered parallel current arguments in the philosophical literature.Keywords: Nicolaus Copernicus; Georg Joachim Rheticus; Johannes Kepler; Simplicity; Bayesianism; Hirotsugu Akaike. (shrink)

This book offers a critical introduction to the work of American philosopher D. G. Leahy (1937-2014). Leahy's fundamental thinking can be characterized as an absolute creativity in which all creating is 'live' -- a happening occurring now that manifests a supersaturated polyontological actuality that is essentially created by the logic that characterizes it. Leahy leaves behind the categorial presuppositions of modern thought, eclipsing both Cartesian and Hegelian subjectivities and introducing instead an essentially new form of thinking founded in a nondual (...) logic of creation. The new thinking delineates the absolute unicity of existence as a creative interactivity beyond all traditional dichotomies (such as one vs. many, unity vs. plurality, identity vs. change): a fully "digitized" actuality that is nothing but newness, which inherently implies nothing but change. Through this new form of thinking, change itself is revealed to be the very essence of reality and mind. Any reader looking for a quantum leap beyond the thrall of modern and postmodern fixations is invited to hear and apprehend this new thinking that refuses to be conditioned by paradigms, categories, species, genera, walls, bridges, boundaries, or abstractions: an essentially free thinking that embodies creative novelty itself. (shrink)

Studies have shown that using robot pets in dementia care contributes to a reduction in loneliness and anxiety, and other benefits. Studies also show that, even when people know they are dealing with robots, they often treat the robot as though it is a real pet with genuine emotions. This disconnect between beliefs and behavior occurs not just for people living with dementia, but with cognitively healthy adults, including those who are knowledgeable about how robots work. One possible explanation is (...) that robot pets prompt contradictory beliefs, and so the use of robot pets encourages self‐deception. Sparrow argues that this makes the use of robot pets in dementia care morally objectionable. We disagree. We argue that Gendler's concept of alief offers a better explanation of the belief‐behavior disconnect observed when people interact with robot pets. An alief is a mental state composed of an automatic, arational, emotional, and behavioral response to representational input. Aliefs are not beliefs and are not subject to truth norms. Thus, on our view, harms associated with the use of robot pets in dementia care are not likely to include the self‐deceptions that Sparrow suggests. It might seem like philosophical hair‐splitting to claim that deception has not occurred because discordant aliefs rather than false beliefs have been formed, but this distinction matters. We argue that aliefs carry their own risks. These risks are important to consider when using robot pets in dementia care. (shrink)

We describe the ongoing citations to biomedical articles affected by scientific misconduct, and characterize the papers that cite these affected articles. The citations to 102 articles named in official findings of scientific misconduct during the period of 1993 and 2001 were identified through the Institute for Scientific Information Web of Science database. Using a stratified random sampling strategy, we performed a content analysis of 603 of the 5,393 citing papers to identify indications of awareness that the cited articles affected by (...) scientific misconduct had validity issues, and to examine how the citing papers referred to the affected articles. Fewer than 5% of citing papers indicated any awareness that the cited article was retracted or named in a finding of misconduct. We also tested the hypothesis that affected articles would have fewer citations than a comparison sample; this was not supported. Most articles affected by misconduct were published in basic science journals, and we found little cause for concern that such articles may have affected clinical equipoise or clinical care. (shrink)

Kepler, the father of modern physical astronomy, believed that the world is ordered by Archetypes . As quaint as this may seem, I argue that Kepler's archetypes provided methodological and epistemological solutions to problems in physical astronomy acknowledged during his time. ;Kepler used the assumption of a harmony between the archetypal and physical world to argue for the legitimacy of certain methodological innovations. The main difficulty facing astronomers at that time was the availability of observationally equivalent competing astronomical hypotheses. Kepler's (...) solution was to argue that the hypotheses could be distinguished between by proper testing and by bringing in considerations from other disciplines, especially physics. Kepler's account of the proper testing of hypotheses, though modern in appearance, was grounded in his archetypal cosmology. The use of physics in astronomy, also a modern innovation, was not considered to be methodologically sound during Kepler's time unless certain conditions were met. Under Kepler's archetypal cosmology these conditions were met, thereby legitimating the use of physics in astronomy. ;Kepler's archetypes play another role in his physical astronomy. The Aristotelian account of physics still dominant was qualitative in character. The use of mathematical physics was acceptable if it was grounded in qualitative theory, which Kepler was unable to fully provide. I argue that Kepler's archetypal cosmology enabled him to overcome this conceptual barrier. While Kepler agreed with Aristotle that mathematics is unable to reveal anything about physical causes, he believed that the archetypes are not limited in this manner. For Kepler, God's only reason for creating physical powers was to instantiate the archetypes; hence a study of archetypes can provide information about physical causes. When Kepler was unable to attach mathematical models to qualitative physical theory, he attached them to archetypal models, thereby legitimating their use in physics. ;Kepler's archetypes are no longer scientifically significant. At the time, however, they functioned to break down some of the conceptual barriers to his new physical astronomy. As a result, understanding Kepler's archetypes is of paramount importance for understanding his role in the scientific revolution of the sixteenth and seventeenth centuries. (shrink)

Obstetric ultrasound has become a significant tool in obstetric practice, however, it has been argued that its increasing use may have adverse implications for women’s reproductive freedom. This study aimed to explore Australian obstetricians’ experiences and views of the use of obstetric ultrasound both in relation to clinical management of complicated pregnancy, and in situations where maternal and fetal health interests conflict.

The paradox of the Aged Care Act 1997: the marginalisation of nursing discourse This paper examines the marginalisation of nursing discourse, which followed the enactment of the Aged Care Act 1997. This neo‐reform period in aged care, dominated by theories of economic rationalism, enshrined legislation based upon market principles and by implication, the provision of care at the cheapest possible price. This paper exposes some of the gaps in the neo‐reform period and challenges the assertion that the amalgamation of nursing (...) homes and hostels in such an environment can provide better quality of care and life for residents. It argues that this amalgamation entails a transformation towards a social model of care and fails to address the professional healthcare needs of the acutely sick and complex extreme old person and makes evident new gaps in the provision of aged care services. The paper proceeds to present strategies where the future for nursing practice in aged care necessarily involves a judicious balancing of individual cases alongside economic prescriptions of care and ever‐changing public policy initiatives. It concludes that this can be achieved through a more interactive public, professional and advocacy discourse. The methodology involves extensive analysis of public documents including media, academic journals, government reports and interviews with recognised leaders in the field of aged care. The study utilises a critical interpretative framework consistent with the logic of Michel Foucault. (shrink)